Table 1 Included study characteristics
Study | Publication Time | Years of Patient Accrual | Country | Study Type | No. of Patients | No. of Analysis | Median Follow Up | Histology | Adjuvant Therapies | EOR assessment | Level of Evidence |
|---|---|---|---|---|---|---|---|---|---|---|---|
WINGE(9) | 1989 | 1982–1987 | London | retrospective study | 285 | 187 | NS | Glioblastoma multiforme 188 Astrocytoma 76 Mixed 11 Oligodendroglioma 10 Astrocytoma or mixed A > O 32 | RT | NS | II |
Shaw(10) | 2002 | 1986–1994 | Mayo | retrospective study | 203 | 203 | 6.4 years | Oligodendroglioma or mixed O > A 69 | RT | NS | II |
HARMON J(11) | 1993 | 1980–1985 | USA (Michigan) | prospective randomized trial | 60 | 60 | 4.5 years | Low-grade Glioma | RT + Ch | NS | II |
Edward G(12) | 1994 | 1960–1982 | Mayo | retrospective study | 71 | 71 | 15 years | Oligoastrocytoma | RT | operative report | II |
R. Laws(13) | 1984 | 1915–1975 | Mayo | retrospective study | 851 | 461 | 15 year MAX | Astrocytoma | RT | microscopically | III |
LINDEGAARD(14) | 1987 | 1953–1977 | Norway | retrospective study | 58 | 58 | 23 years MAX | Oligodendroglioma | RT | NS | III |
SHAW(a)(15) | 1989 | 1915–1975 | Mayo | retrospective study | 41 | 41 | 25 years MAX | Astrocytoma | RT | operative report | III |
Soffietti(16) | 1989 | 1950–1982 | Italy | retrospective study | 71 | 71 | 7 year MAX | Astrocytoma | RT | Surgeon’s description | III |
North(17) | 1990 | 1975–1984 | USA(Baltimore) | retrospective study | 32 | 32 | 69mo | Astrocytoma | RT | NS | III |
SHAW(18) | 1992 | 1960–1982 | Mayo | retrospective study | 82 | 82 | 7.1 years | Oligodendroglioma | RT | operative report | III |
Shibamofo(19) | 1993 | 1965–1989 | Japan (Kyoto) | retrospective study | 67 | 67 | 10 year MAX | Astrocytoma | RT + Ch | NS | III |
Paolo(20) | 1994 | 1953–1986 | Italy | retrospective study | 105 | 105 | NS | Oligodendroglioma | RT | operative report | III |
RAJAN(21) | 1994 | 1974–1990 | UK | retrospective study | 82 | 82 | 52mo | Glioma | RT | operative report | III |
Veelen(22) | 1998 | 1975–1989 | Netherlands | retrospective study | 90 | 90 | 120mo Max | Astro 72 Oligo 14 Mixed 4 | RT | patients’ charts | III |
IWABUCHI(23) | 1999 | 1967–1993 | Japan | retrospective study | 56 | 56 | 5 year | Astrocytoma | RT | NS | III |
Smith(24) | 2008 | 1989–2005 | USA (California) | retrospective study | 216 | 216 | 4.4 years | Astrocytoma 93 Oligodendroglioma 91 Mixed Oligoastrocytoma 32 | RT + Ch | Patientrecords | III |
Thomas B. Daniels(25) | 2012 | 1984–2007 | Japan | retrospective study | 42 | 42 | NS | Astrocytoma 27 Oligodendroglioma12 Oligoastrocytoma7 | RT + Ch | Pre- and post-operative CT | III |
Nicolato(26) | 1995 | 1977–1989 | Italy | retrospective study | 76 | 74 | 160mo Max | Astrocytoma | RT | NS | IV |
Jeremica(27) | 1998 | 1988–1993 | Japan | retrospective study | 37 | 37 | 74mo | Astrocytoma 18 Oligodendroglioma 14 Mixed glioma 5 | RT | operative report | IV |
YEH(28) | 2005 | 1985–1997 | China (Taiwan) | retrospective study | 93 | 93 | 110mo | Astrocytoma 46 Oligodendroglioma 32 Mixed 15 | RT | operative report | IV |