Fig. 7
From: The effects of trastuzumab on HER2-mediated cell signaling in CHO cells expressing human HER2
The effects of trastuzumab on the phosphorylation of ERK and AKT in CHO-K6 cells. The phosphorylation of ERK and AKT was revealed by immunoblotting as described in Materials and Methods. a The phosphorylation of ERK and AKT in CHO parental cells and in CHO-K6 cells. b The effects of trastuzumab on the phosphorylation of ERK and AKT in CHO-K6 cells. Cells were treated with trastuzumab with indicated concentrations for 7Â h. Cells treated with normal human IgG was used as negative control and cells treated with CP-714724 (CP) was used as positive control