Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project

Table 2 Relationship between reproductive factors and breast cancer

Reproductive factor	Category	OR (95% CI)	p value
Age at menarche	> 12 years	1 (reference)	–
Age at menarche	≤ 12 years	0.95 (0.79–1.13)	0.55
Number of deliveries	0	1 (reference)	–
	1–2	0.58 (0.38–0.90)	0.01
	> 2	0.43 (0.27–0.68)	< 0.001
Age at first delivery^a	< 20 years	1.65 (1.00–2.75)	0.05
	20–24 years	1.06 (0.83–1.34)	0.65
	25–29 years	1 (reference)	–
	30–34 years	0.93 (0.70–1.23)	0.60
	≥ v35 years	1.11 (0.73–1.69)	0.63
Age at menopause^b	< 50 years	0.77 (0.62–0.96)	0.02
Age at menopause^b	≥ 50 years	1 (reference)	–
Use of hormonal contraceptives	No	1 (reference)	–
Use of hormonal contraceptives	Yes	0.81 (0.67–0.97)	0.02
Use of hormone replacement therapy^b	No	1 (reference)	–
Use of hormone replacement therapy^b	Yes	1.00 (0.95–1.06)	0.89

Odds ratios (OR) adjusted for propensity score, menopausal status and mutually adjusted for the remaining variables in the table
^aOdds ratio estimated only in parous women
^bOdds ratio estimated only in postmenopausal women

ISSN: 1471-2407