Table 7 Univariate logistic regression model of clinical parameters on treatment response in stratified high---grade serous carcinoma (HGSC)a
From: Characteristics and outcome of the COEUR Canadian validation cohort for ovarian cancer biomarkers
All HGSC | Advanced stage HGSC | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Hazard | 95.0% CI | Hazard | 95.0% CI | |||||||
Ratio | Lower | Upper | n | p value | Ratio | Lower | Upper | n | p value | |
BRCA mutation carrier status | ||||||||||
Non carrier | 247 | reference | 228 | reference | ||||||
BRCA1 carrier | 0.29 | 0.11 | 0.77 | 38 | 0.013 | 0.34 | 0.13 | 0.91 | 32 | 0.031 |
BRCA2 carrier | 0.72 | 0.27 | 1.89 | 22 | 0.499 | 0.73 | 0.27 | 1.94 | 21 | 0.524 |
All mutated vs no mutation | 0.44 | 0.22 | 0.89 | 307 | 0.022 | 0.49 | 0.24 | 1.00 | 281 | 0.042 |
Provinces | ||||||||||
Quebec | 256 | reference | 239 | reference | ||||||
Ontario | 0.47 | 0.27 | 0.82 | 93 | 0.008 | 0.40 | 0.21 | 0.74 | 80 | 0.00 |
Alberta | 0.22 | 0.08 | 0.58 | 46 | 0.002 | 0.19 | 0.07 | 0.55 | 40 | 0.002 |
Manitoba | NA | NA | NA | 8 | 0.999 | NA | NA | NA | 5 | NA |
British Columbia | 0.95 | 0.63 | 1.44 | 160 | 0.808 | 0.92 | 0.60 | 1.40 | 155 | 0.689 |