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Table 2 Characteristics of included studies on the survival outcomes of endometrial cancer

From: Effect of metformin use on the risk and prognosis of endometrial cancer: a systematic review and meta-analysis

Author (year)

Region

Design

Percentage of stages I–II, %

No. of patients

Age (year)

Diabetic patients, %

Adjusted variables

Outcomes

Subgroups

Follow-up duration

Ko et al. (2014) [41]

USA

Retrospective

82

363

63

100

Age, stage, grade, histology, adjuvant treatment

TTR, RFS, OS

None

2005–2010

Nevadunsky et al. (2014) [9]

USA

Retrospective

75

985

64

75

Age, clinical stage, grade, chemotherapy, radiation, hyperlipidemia

OS

Diabetes

1999–2009

Lemanska et al. (2015) [42]

Poland

Retrospective

75

107

64

64

Age, diabetes, hypertension, BMI, glucose level, grade, stage, hysterectomy, radiation, endometrial cancer type

OS

Histological type

2002–2010

Ezewuiro et al. (2016) [44]

USA

Retrospective

0

349

63

17

study site, BMI, race, age, stage

OS, recurrence

Diabetes

1992–2011

Hall et al. (2016) [10]

USA

Retrospective

79

351

58

18

None

Recurrence

None

2005–2011

Al Hilli et al. (2016) [43]

USA

Retrospective

81

1303

65

21

Age, BMI, smoking, ASA score, cardiopulmonary state, various tumor features, surgery, adjuvant therapy

OS, PFS

Histological type, diabetes

1999–2008

Seebacher et al. (2016) [45]

Austria

Retrospective

70

465

65

19

Age, tumor stage, grade, histological subtype

CSS, OS, RFS, recurrence

None

1995–2011

  1. ASA American Society of Anesthesiologists, BMI body mass index, CSS cancer-specific survival, EC endometrial cancer, OS overall survival, PFS progression -free survival, RFS recurrence-free survival, TTR time to recurrence, USA the United States of America