Fig. 2From: A computational study of hedgehog signalling involved in basal cell carcinoma reveals the potential and limitation of combination therapySensitivity heat maps of the SMO network. Sensitivity was calculated in response to variations in SMO and PI3K activities on the xy-plane (left and right, respectively), combined with different levels of cAMP (as in Fig. 1) on the z-axis. The regions of high sensitivity between low and high SMO and PI3K activities (blue-red-yellow areas) correspond to a transition zone between low and high steady-state activity of tumour proliferationBack to article page