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Fig. 6 | BMC Cancer

Fig. 6

From: Identification of genes inducing resistance to ionizing radiation in human rectal cancer cell lines: re-sensitization of radio-resistant rectal cancer cells through down regulating NDRG1

Fig. 6

The effect of down-regulated NDRG1 in the radio-resistant rectal cancer cells. a Western blot analysis was performed to confirm the basal protein expression of NDRG1. SNU-283R80Gy and SNU-503R80Gy cells had increased level of NDRG1 compared to their parental cells. b Knockdown efficacy of NDRG1 with short-hairpin RNA was confirmed with Western blot analysis. c Down-regulated NDRG1 increased the sensitivity of radio-resistance rectal cancer cells to irradiation. The amount of cleaved PARP and phosphorylated gamma H2AX was augmented when the expression of NDRG1 was decreased. d Cell Proliferation rate was decreased when NDRG1 was down-regulated

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BMC Cancer

ISSN: 1471-2407

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