Fig. 7

Modulation of CDKN1A-CDK1-mediated gene interaction network in human lung adenocarcinoma cell line A5492 cells after GMDS knockdown. Genes represented in green were downregulated while genes in red were upregulated in A549 cells after GMDS knockdown. Solid line represented direct interactions while dotted line represented indirect interactions. The meaning of abbreviations in the figure: A, activation; B, binding; C, causation/leads to; CO, correlation; CC, chemical-chemical interaction; CP, chemical-protein interaction; E, expression; EC, enzyme catalysis; I, inhibition; L, molecular cleavage; LO, localization; M, biochemical modification; miT, microRNA targeting; MB, group/complex membership; nTRR, non-targeting RNA-RNA interaction; P, phosphorylation/dephosphorylation; PD, protein-DNA binding; PP, protein-protein binding; PR, protein-RNA binding; PY, processing yields; RB, regulation of binding; RE, reaction; RR, RNA-RNA binding; T, transcription; TR, translocation; UB, ubiquitination