Fig. 1
From: WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage
WDR5 is overexpressed in colon cancer cells. a WDR5, RBBP5, ASH2L, and DPY30 gene expression (RNASeq) data from the Colon Adenocarcinoma (COAD) dataset within TCGA for unpaired primary colon tumors and normal solid tissue samples. Tumor includes 478 samples from 456 patients for each gene. Normal includes 41 samples from 41 patients for each gene. For each boxplot the middle line represents the median, the box represents the 25th to 75th percentile and the whiskers represent the 5th to 95th percentile. The results published here are in whole or part based upon data generated by the TCGA Research Network: http://cancergenome.nih.gov/. b RT-qPCR and (c) western blot of WDR5 in a panel of colon tumor cell lines as compared to immortalized, non-transformed HCECs. RT-qPCR data are shown as mean ± SD. ** p < 0.01 *** p < 0.001 **** p < 0.0001