High expression of the p53 isoform γ is associated with reduced progression-free survival in uterine serous carcinoma

Table 3 Overview over TP53 mutations observed in patients

Patient ID	FIGO 2009 tumor stage	Mutation^a	Amino acid change	Effect	Progression free survival (months)
1	1c	7577120C > T	R273H	missense^c	29
2	4b	7577097C > T	D281N	missense^b	0
3	4b	7577538C > T	R248Q	missense^c	0
4	1b	7577581A > G	Y234H	missense^b	14
5	3c	7,578,394 T > A	H179L	missense^b	7
6	2b	7577539G > A	R248W	missense^c	1
7	3c	7578239C > A	E204 ^a	nonsense^b	3
8	1c	7577120C > T	R273H	missense^c	14
9	1a	7577573G > T	Y236 ^a	nonsense^b	10
9	1a	7578211C > A	R213L	missense^b	10
10	3a	7,577,580 T > C	Y234C	missense^b	5
11	4b	7577539G > A	R248W	missense^c	58
12	1c	7577153C > A	G262 V	missense^b	96
13	3c	7577538C > T	R248Q	missense^c	25
14	3c	7578508C > T	C141Y	missense^b	11
15	1c	7,578,442 T > C	Y163C	missense^b	11
16	3c	7578406C > T	R175H	missense^c	2
17	4b	7577586A > T	I232N	missense^b	0
18	3c	7577538C > T	R248Q	missense^c	2
19	1a	7578406C > T	R175H	missense^c	19
21	2a	7579556ATCAA		frameshift	1
23	1b	7577535C > G	R249T	missense^b	15
25	4a	7578272G > A	H193Y	missense^b	0
26	3c	7577121G > A	R273C	missense^b	0
31	3c	7577569TGT		non-frameshift deletion	11
32	3c	7,578,190 T > C	Y220C	missense^b	0
34	1a	7577141C > T	G266E	missense^b	11
35	3a	7577130A > G	F270 L	missense^b	15
35	3a	7577132C > T	S269 N	partially functional^b	15

ISSN: 1471-2407