Table 4 Significant results of the analysis of fractional shortening alteration in the acute lymphoid leukemia population
Gene | SNP | Genotype group 1 / group 2 | Patients with decreased FS in genotype groups N (%) | Patients with increased FS in genotype groups N (%) | P value | OR (CI 95%) |
|---|---|---|---|---|---|---|
Alteration of FS: diagnosis vs. end of therapy | ||||||
CYP3A4 | rs3735451 | AA / AG + GG | 74 (82) / 16 (18) | 52 (63) / 31 (37) | 5.70E-03 | 0.36 (0.18–0.74) |
CYP3A5 | rs776746 | GG / GA + AA | 81 (91) / 8 (9) | 60 (73) / 22 (27) | 3.80E-03 | 0.26 (0.11–0.65) |
Alteration of FS: diagnosis vs. last echocardiography | ||||||
NQO1 | rs1043470 | CC / CT + TT | 111 (85) / 41 (15) | 112 (73) / 20 (27) | 8.90E-03 | 0.44 (0.24–0.81) |