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Table 8 Results of DFS analysis by Cox proportional hazards model

From: Tumoral BRD4 expression in lymph node-negative breast cancer: association with T-bet+ tumor-infiltrating lymphocytes and disease-free survival

Prognostic Factor

Univariate

Multivariate

RR

95% CI

P-value

RR

95% CI

P-value

T-bet//BRD4 combinations

 T-bet-/BRD4+ vs.Other

2.55

1.15

5.62

0.0207

2.91

1.29

6.59

0.0103

Her2

 Positive vs. Negative

1.21

0.44

3.36

0.7129

0.51

0.17

1.52

0.2271

Menopausal status

 Pre/Peri vs. Post)

1.08

0.63

1.85

0.7678

0.70

0.25

1.91

0.4806

ER

 Negative/Equi vs. ND/Positive

1.42

0.79

2.53

0.2393

1.36

0.68

2.73

0.3825

Tumor Size

 2–5 cm vs. <  2 cm

2.42

1.39

4.23

0.0018

1.88

1.01

3.50

0.0476

  > 5 cm vs. <  2 cm

1.78

0.53

6.05

0.3525

1.33

0.38

4.64

0.6516

Histologic grade

 Grade2–3 vs. Grade1/Subtypea

4.23

1.68

10.67

0.0023

3.64

1.41

9.44

0.0078

 ND vs. Grade1/Subtypea

4.34

1.37

13.81

0.0129

4.41

1.34

14.54

0.0147

Lymphatic invasion

 Present vs. Absent

3.61

2.05

6.33

<.0001

3.96

2.12

7.38

<.0001

Age at diagnosis, yrs

 Linear

0.90

0.70

1.15

0.3858

0.81

0.52

1.25

0.3387

 Quadratic

0.90

0.73

1.10

0.2879

0.93

0.75

1.15

0.4801

Adjuvant treatment

 Hormonal vs. None

0.53

0.30

0.93

0.0274

0.51

0.27

0.99

0.046

 Chemotherapy vs. None

0.99

0.52

1.88

0.9676

0.53

0.24

1.19

0.1239

  1. aIncludes mucinous, lobular and tubular subtypes
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