Fig. 7
From: Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins
Gn-lip inhibited DLD-1 xenograft growth. Tail vein injection of Gn-lip inhibited DLD1 xenograft growth and was associated with decreased Notch/Wnt signaling and increased apoptosis. a Gn potently inhibited the DLD-1 xenograft tumor growth in nude mice as a single-agent therapy. The data shown are average tumor size (means ± S.E.M., n = 10) versus control (n = 20). ** p < 0.01 b Body weight of both groups remained similar during the treatment time, indicating a low systemic toxicity of Gn-lip. c Gn-lip induced apoptosis and down-regulated several Notch/Wnt downstream genes in tumor samples. d Working model