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Fig. 5 | BMC Cancer

Fig. 5

From: Rational development of synergistic combinations of chemotherapy and molecular targeted agents for colorectal cancer treatment

Fig. 5

In vivo evaluation of the interaction of the BKM120-MEK162 combination. (a and b) Growth curves of HCT116 xenografts in nude mice treated with vehicle (NT) or different doses of MEK162 (a), or of BKM120 (b). Each growth curve represents the mean of tumor growth volume for mice of the corresponding group. Experimental groups were treated and assessed in the following order: first the NT group with vehicle, and then the other groups according to the concentrations of BKM120 in increasing order and, for the groups treated with the same concentration of BKM120, according to the concentrations of MEK162 in increasing order. (c) Dose matrix representing the fractional tumour growth inhibition in mice treated with different dose combinations of BKM120 and MEK162

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BMC Cancer

ISSN: 1471-2407

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