Fig. 6

Effect of gastrin and tamoxifen treatment on growth of ER⁺ MCF-7 and T-47D cells. (a-b) MCF-7 and T-47D cells treated with gastrin (10^− 7 M), tamoxifen (2 μM), or combination of both for 7 d were harvested at each time point for CCK-8 assay and Western blot. (A) CCK-8 assay of MCF-7 cells; (B) CCK-8 assay of T-47D cells (*P < 0.05). c Activation of CCKBR/ERK/P65 signaling in MCF-7 cells treated with tamoxifen (a), gastrin (b), or a combination of both agents (c). d Activation of CCKBR/ERK/P65 signaling in T-47D cells treated with tamoxifen (a), gastrin (b), or a combination of both agents (c)