Skip to main content

Table 3 Cox regression predicting mortality risk for Women With Stage IV Breast Cancer (univariable and multivariable)

From: Could local surgery improve survival in de novo stage IV breast cancer?

Characteristic

Univariable HR*(95%CI)

P

Multivariable HR*(95%CI)

P

Surgery

ā€ƒYes vs No

0.56(0.382-0.820)

0.003

0.53(0.36-0.78)

0.001

Viscera metastasis

ā€ƒYes vs no

1.73 (1.18-2.54)

0.005

Ā 

Bone metastasis

ā€ƒYes vs no

0.91 (0.62-1.32)

0.610

Ā 

CNS metastasis

ā€ƒYes vs no

1.40 (0.44-4.43)

0.566

Ā 

Soft tissue metastasis

ā€ƒYes vs no

0.99 (0.68-1.46)

0.977

Ā 

Age

ā€ƒā‰¤50 vs >50

0.65 (0.44-0.95)

0.026

Ā 

Menopause status

ā€ƒMenopause vs menses

1.21 (0.82-1.77)

0.344

Ā 

Biopsy

ā€ƒmass resection

1Ā§

0.753

Ā 

ā€ƒcore needle

1.32 (0.64-2.73)

0.457

Ā 

ā€ƒfine needle

1.43 (0.18-11.59)

0.736

Ā 

Histology

ā€ƒductal

1Ā§

0.824

Ā 

ā€ƒlobular

0.66 (0.16-2.69)

0.563

Ā 

ā€ƒothers

1.11 (0.41-3.05)

0.835

Ā 

Tumor size

ā€ƒ>5 cm vs ā‰¤5 cm

1.00 (0.67-1.49)

0.981

Ā 

Lymph node involvement

ā€ƒN0

1Ā§

0.259

Ā 

ā€ƒN1

2.48 (1.00-6.11)

0.049

Ā 

ā€ƒN2

1.95 (0.80-4.74)

0.142

Ā 

ā€ƒN3

2.14 (0.91-5.05)

0.081

Ā 

HER2 receptor status

ā€ƒAmplified

1Ā§

0.557

Ā 

ā€ƒNo-amplified

0.81 (0.55-1.21)

0.304

Ā 

ā€ƒNot known or equivocal(2+)

0.77 (0.31-1.93)

0.574

Ā 

Hormone receptor status

ā€ƒ+ vs -

0.49 (0.321-0.7233)

<0.001

0.57 (0.36-0.89)

0.013

No. of metastasis sites

ā€ƒ>3 vs ā‰¤3

1.751 (0.881-3.477)

0.11

Ā 

Endocrine therapy$

ā€ƒYes vs no

0.45 (0.30-0.68)

<0.001

0.55 (0.35-0.86)

0.009

Anti-HER2 therapy$

ā€ƒNo

1Ā§

0.11

Ā 

ā€ƒYes

0.54 (0.325-1.008)

0.035

Ā 

ā€ƒUnknown

0.00 (0.00-5.357E+159)

0.959

Ā 

Radiotherapy

ā€ƒNo

1Ā§

0.029

Ā 

ā€ƒYes

0.61 (0.40-0.94)

0.025

Ā 

ā€ƒUnknown

1.35 (0.71-2.57)

0.357

Ā 
  1. Abbreviation: Ā§ Reference; * OFSā€‰=ā€‰ovarian function suppression; CNSā€‰=ā€‰central nervous system; HRā€‰=ā€‰Hazard ratio; $Endocrine therapy were subsequent to chemotherapy; anti-HER2 therapy were incorporated into or subsequent to chemotherapy
  2. P values in bold italic are considered statistically significant