Table 3 Associations between combined MRN expression in the tumor center or periphery and clinicohistopathological data
| Â | Tumor Center | Tumor Periphery | ||||
|---|---|---|---|---|---|---|
Low (%) | High (%) | P value | Low (%) | High (%) | P value | |
Sex | ||||||
 Male | 62.5 | 66.8 | 0.567 | 80.0 | 64.6 | 0.121 |
 Female | 37.5 | 33.2 |  | 20.0 | 35.4 |  |
Age | ||||||
 ≤70 | 43.8 | 46.5 | 0.751 | 36.0 | 47.1 | 0.290 |
 > 70 | 56.2 | 53.5 |  | 64.0 | 52.9 |  |
Tumor stage | ||||||
 T1–2 | 50.0 | 30.0 | 0.009* | 44.0 | 32.5 | 0.246 |
 T3–4 | 50.0 | 70.0 |  | 56.0 | 67.5 |  |
Node stage | ||||||
 Negative | 60.0 | 53.1 | 0.395 | 52.0 | 54.5 | 0.811 |
 Positive | 40.0 | 46.9 |  | 48.0 | 45.5 |  |
Metastasis stage | ||||||
 M0 | 97.8 | 91.7 | 0.147 | 100 | 92.1 | 0.153 |
 M1 | 2.2 | 8.3 |  | 0 | 7.9 |  |
Grade | ||||||
 1–2 | 93.8 | 92.2 | 0.707 | 88.0 | 92.9 | 0.376 |
 3 | 6.2 | 7.8 |  | 12.0 | 7.1 |  |
Vascular invasion | ||||||
 Absent | 82.6 | 75 | 0.27 | 84 | 75.5 | 0.343 |
 Present | 17.4 | 25 |  | 16 | 24.5 |  |
Perineural invasion | ||||||
 Absent | 84.8 | 83.8 | 0.869 | 92 | 83.1 | 0.250 |
 Present | 15.2 | 16.2 |  | 8 | 16.9 |  |
Adjuvant therapy | ||||||
 No | 70.0 | 69.4 | 0.945 | 52.4 | 71.4 | 0.072 |
 Yes | 30.0 | 30.6 |  | 47.6 | 28.6 |  |
Neoadjuvant therapy | ||||||
 No | 65.2 | 80.9 | 0.021* | 68 | 78 | 0.205 |
 Yes | 34.8 | 19.1 |  | 32 | 22 |  |
MSH6 | ||||||
 Negative | 0 | 100 | 0.518 | 0 | 100 | 0.663 |
 Positive | 17.3 | 82.7 |  | 8.7 | 91.3 |  |
PMS2 | ||||||
 Negative | 11.1 | 88.9 | 0.669 | 0 | 100 | 0.345 |
 Positive | 16.5 | 84.5 |  | 9.1 | 90.9 |  |