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Table 4 Cox regression analyses of combined MRN expression with disease-free survival

From: Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis

 

n (%)

Univariate

Multivariate

HR

95% CI

P Value

HR

95%

P Value

MRN TCa

 High

81.9

2.069

1.102–3.882

0.024*

2.114

1.096–4.078

0.026*

 Low

18.1

      

Sex

 Male

66.4

1.041

0.633–1.711

0.876

   

 Female

33.6

      

Age

 ≤70

46.0

1.294

0.789–2.125

0.307

   

 > 70

54.0

      

Tumor stage

 T1–2

33.6

1.501

0.897–2.512

0.122

   

 T3–4

66.4

      

Node stage

 Negative

54.3

1.44

0.976–2.126

0.066

   

 Positive

45.7

      

Grade

 1–2

92.5

1.537

0.823–2.872

0.178

   

 3

7.5

      

Vascular invasion

 Absent

76.3

1.167

0.638–2.134

0.617

   

 Present

23.7

      

Perineural invasion

 Absent

84.0

2.334

1.310–4.157

0.004*

2.16

1.209–3.859

0.009*

 Present

16.0

      

Adjuvant therapy

 No

69.5

0.602

0.341–1.063

0.08

   

 Yes

30.5

      

Neoadjuvant therapy

 No

78.0

0.855

0.529–1.381

0.521

   

 Yes

22.0

      

MRN TC by LNb

 LN-negative

54.1

   

1.339

0.589–3.042

0.486

 LN-positive

45.9

   

3.472

1.051–11.454

0.047*

  1. HR hazard ratio, CI confidence interval, TC tumor center, LN lymph node
  2. aThree marker combined expression in the tumor center; b denotes interaction
  3. *p < 0.05 was considered significant
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BMC Cancer

ISSN: 1471-2407

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