Fig. 7From: Extracellular matrix collagen I promotes the tumor progression of residual hepatocellular carcinoma after heat treatmentSchematic diagram shows that collagen I initiates ERK signaling to accelerate the aggressive progression of residual HCC cells after sublethal RFA, which could be reversed by sorafenib. More factors implicated in post-inflammation reaction after RFA promote tumor progression of residual HCC, which has been reported by the other authors [14, 15, 49, 50]Back to article page