Fig. 1
From: Second primary colorectal cancer after the initial primary colorectal cancer
Temporal trend of second primary colorectal cancer (SPCRC) incidence over a 22-year follow-up period in the United States from 1992 to 2012. (a). Trend of SPCRC incidence per 1000 person-years is estimated by Joinpoint regression (Trend 1: 1st-8th year, Trend 2: 8th–20th year). ^ P < 0.05. (b) Trend of SIR (standardized incidence ratio) SPCRC in the colorectal cancer (CRC) compared with the general population. The X-axis represents the intervals of follow-up and the Y-axis represents rates per 100,000 of the US population. The dotted line means that the 95% CI