Fig. 6

DNA damage response genes are differentially regulated in prostate cancer models and in advanced prostate cancer. a Heatmap of Z-score normalized DNA repair genes significantly (Kuskal-Wallis test, p ≤ 1E-5) associated with metastatic prostate tumors. Publicly available MSKCC data of 131 primary tumors and 37 metastatic tumors was downloaded from cBioPortal. b S-plot of castration-mediated expression changes of 450 DNA damage repair genes. Median fold changes were calculated from 7 hormone-resistant versus hormone-sensitive prostate cancer xenograft models. Data was downloaded and derived from Chen et al. (2004) [20]. Red dots represent genes whereby four or more xenograft models were upregulated while blue dots represent genes whereby four or more xenograft models were downregulated. c Venn diagram of DNA repair machinery differentially regulated in the cell line, xenograft, and patient models. d Graph of Fisher’s exact test comparing DNA damage response genes from each dataset (cell line, xenograft, and patient metastases) to the 125 ontology groups described by Pearl et al. (2015) [21]. Red dots and descriptions indicate p ≤ 0.01