Table 1 The concentration of flavonoids necessary for 50% inhibition (IC50 values). Data of mean ± SEM are from four analytical experiments, each conducted in triplicate. bFR: fold-drug resistance was derived by dividing the IC50 concentration for doxorubicin of KB 3–1 and KBCHR8–5 cells in the absence/presence of flavonoids by IC50 value for doxorubicin of KB 3–1 cells
Compound | KB 3–1 | KB ChR 8–5 | ||
|---|---|---|---|---|
IC50 ± SEMα (μM) | FRb | IC50 ± SEMα (μΜ) | FRb | |
Doxorubicin | 0.04 ± 0.01 | [1.0] | 7 ± 0.20 | [175.0] |
+ 1 μM Theaflavine | 0.03 ± 0.01 | [0.8] | 3 ± 0.04 | [75.0] |
+ 5 μM Theaflavine | 0.02 ± 0.01 | [0.5] | 0.6 ± 0. 03 | [15.0] |
+ 10 μM Theaflavine | 0.02 ± 0.01 | [0.5] | 0.3 ± 0.02 | [7.5] |
+ 1 μM Quercetin | 0.02 ± 0.01 | [0.5] | 4 ± 0.05 | [100.0] |
+ 5 μM Quercetin | 0.03 ± 0.01 | [0.8] | 1 ± 0.01 | [25.0] |
+ 10 μM Quercetin | 0.02 ± 0.01 | [0.5] | 0.6 ± 0.01 | [15.0] |
+ 1 μM Rutin | 0.03 ± 0.01 | [0.8] | 6 ± 0.05 | [150.0] |
+ 5 μM Rutin | 0.02 ± 0.01 | [0.5] | 3 ± 0.01 | [75.0] |
+ 10 μM Rutin | 0.02 ± 0.01 | [0.5] | 0.7 ± 0.01 | [17.5] |
+ 1 μM E3G | 0.02 ± 0.01 | [0.5] | 5 ± 0.04 | [125.0] |
+ 5 μM E3G | 0.03 ± 0.01 | [0.8] | 3 ± 0.02 | [75.0] |
+ 10 μM E3G | 0.02 ± 0.01 | [0.5] | 1 ± 0.02 | [25.0] |
+ 1 μM Tamarixetin | 0.03 ± 0.01 | [0.8] | 6 ± 0.03 | [150.0] |
+ 5 μM Tamarixetin | 0.02 ± 0.01 | [0.5] | 4 ± 0.02 | [100.0] |
+ 10 μM Tamarixetin | 0.02 ± 0.01 | [0.5] | 2 ± 0.01 | [50.0] |