The role of matrix metalloproteinase-9 as a prognostic biomarker in papillary thyroid cancer

BMC Cancer

Table 3 Association of MMP-9 mRNA levels with pathology/clinical characteristics of the study participants

Variables	Mean ± SD	Percentiles			P value
Variables	Mean ± SD	25th	50th (Median)	75th	P value
Patients
MNG	2.49 ± 3.70	0.17	0.70	3.40	0.001
PTC	6.77 ± 7.16	1.22	3.83	10.50	0.001
PTC patients analysis
Tissues of PTC patients
Adjacent non-tumoral	3.06 ± 3.63	0.32	1.68	4.35	0.039
Tumoral	8.05 ± 16.48	1.07	2.77	6.07	0.039
Age
< 45 years	1.83 ± 2.13	0.25	0.91	2.86	0.015
≥45 years	6.59 ± 13.01	0.92	2.42	6.08	0.015
Sex
Male	1.47 ± 1.49	0.40	0.85	2.80	0.993
Female	4.51 ± 10.71	0.23	0.96	2.51	0.993
BRAF V600E mutation
BRAF (+)	1.66 ± 1.69	0.28	1.25	2.45	0.987
BRAF (−)	4.14 ± 12.59	0.31	0.80	3.64	0.987
Tumor size
< 2 cm	1.65 ± 1.68	0.35	1.18	2.46	0.960
≥2 cm	5.15 ± 14.82	0.23	0.77	2.81	0.960
TNM Staging
I/II	1.80 ± 1.98	0.28	0.89	2.82	0.011
III/IV	9.23 ± 15.80	1.32	5.53	7.78	0.011
Focality Status
Unifocal	1.76 ± 1.44	0.43	1.42	3.48	0.481
Multifocality	2.27 ± 5.08	0.30	0.84	1.93	0.481
Extracapsular invasion
Yes	10.60 ± 22.88	0.55	1.71	4.34	0.354
No	2.06 ± 2.16	0.28	1.35	3.55	0.354
LNM
Yes	2.82 ± 6.18	0.35	1.08	3.12	0.413
No	1.28 ± 1.27	0.18	0.70	2.12	0.413
Lymphovascular invasion
Yes	4.52 ± 0.82	3.65	4.81	5.10	0.003
No	1.65 ± 1.60	0.40	1.08	2.70	0.003

PTC papillary thyroid carcinoma, MNG multinodular goiter, TNM tumor node metastasis, SD standard deviation, LNM lymph node metastasis, P value is for median of MMP-9 expression

ISSN: 1471-2407