Fig. 6From: MEF2 plays a significant role in the tumor inhibitory mechanism of encapsulated RENCA cells via EGF receptor signaling in target tumor cellsRENCA macrobeads modulate the expression of MEF2 isoforms through EGF receptor signaling. MEF2A, MEF2B, MEF2C and MEF2D expression was assessed by qRT-PCR on (a) DU145 or (b) DU145/GR cells cultured in naïve media or together with > 18 wk. RENCA macrobeads alone or pre-treated with 1 μM gefitinib followed by culture in media as described for 5 days. MEF2B expression was not detected in DU145 or DU145/GR cells. Each column represents the mean (n = 3) ± SD. *p < 0.005, compared with naïve media or gefitinib in naïve mediaBack to article page