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Fig. 5 | BMC Cancer

Fig. 5

From: A novel detection methodology for HER2 protein quantitation in formalin-fixed, paraffin embedded clinical samples using fluorescent nanoparticles: an analytical and clinical validation study

Fig. 5

a Boxplot correlation between HER2 IHC score and PID from the method comparison study. Boxplot A is PID/cell vs. HER2 IHC 0, 1+, 2+, and 3+; boxplot B is PID/ROI100μm2 vs. HER2 IHC 0, 1+, 2+, and 3+. The black diamonds represent the mean PID score for each HER2 IHC score. The black circles represent the PID score outliers in each HER2 IHC score that are less than or greater than 1.5 times the lower and upper interquartile range limits, respectively. Both boxplots produced a p value < 0.001 from a non-parametric Kruskal-Wallis test. b Boxplot correlation between HER2 ISH categories (negative, equivocal and positive) and PID from the method comparison study. Boxplot A is PID/cell vs. HER2 ISH and boxplot B is PID/ROI100μm2 vs. HER2 ISH. The black diamonds represent the mean PID score for each HER2 ISH category. The black circles represent the PID score outliers in each HER2 ISH category that are less than or greater than 1.5 times the lower and upper interquartile range limits, respectively. Both boxplots produced a p value < 0.001 from a non-parametric Kruskal-Wallis test. c Boxplot correlation between HER2 IHC/ISH analysis (negative/negative, equivocal/equivocal, equivocal/positive and positive/positive) and PID from the method comparison study. Boxplot A is PID/cell vs. HER2 IHC/ISH and boxplot B is PID/ROI100μm2 vs. HER2 IHC/ISH. The black diamonds represent the mean PID score for each HER2 IHC/ISH category. The black circles represent the PID score outliers in each HER2 IHC/ISH category that are less than or greater than 1.5 times the lower and upper interquartile range limits, respectively. Both boxplots produced a p value < 0.001 from a non-parametric Kruskal-Wallis test

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BMC Cancer

ISSN: 1471-2407

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