Clinicopathological features, treatment patterns, and prognosis of squamous cell carcinoma of the breast: an NCDB analysis

Table 1 Clinicopathological features of study population

	Histology				P
	Infiltrating Ductal Carcinoma		Squamous Cell Carcinoma
	N	%^a	N	%^a
Race
White	2259	83.33	540	79.65	< 0.01
African American	343	12.65	119	17.55
Others	109	4.02	19	2.80
Unknown	33		8
Charlson-Deyo Score
0	2346	85.50	555	80.90	0.02
1	328	11.95	104	15.16
2	54	1.97	20	2.92
3	16	0.58	7	1.02
Grade
I	476	18.90	62	11.33	< 0.01
II	1058	42.00	151	27.61
III	985	39.10	334	61.06
Unknown/IV	225		139
Lymphovascular Invasion
Absence	768	79.67	185	85.65	0.04
Present	196	20.33	31	14.35	0.04
Not Applicable	1780		470
T-Stage
T0-T1	1441	52.51	145	21.14	< 0.01
T2	502	18.29	178	25.95
T3	67	2.44	100	14.58
T4	45	1.64	58	8.45
Tx	689	25.11	205	29.88
N-Stage
N0	1373	50.04	331	48.25	0.228
N1	381	13.88	85	12.39
N2	115	4.19	22	3.21
N3	56	2.04	16	2.33
Nx	819	29.85	232	33.82
M-Stage
M0	2250	82.00	490	71.43	< 0.01
M1	49	1.79	23	3.35
Mx	445	16.22	173	25.22
Estrogen Receptor
Negative	569	21.95	421	74.91	< 0.01
Positive	2023	78.05	141	25.09	< 0.01
Unknown	152		124
Progesterone Receptor
Negative	843	32.69	491	87.84	< 0.01
Positive	1736	67.31	68	12.16	< 0.01
Unknown	165		127
HER2^b
Negative	829	78.2	207	87.7	< 0.01
Borderline	31	2.9	2	0.9
Positive	200	18.9	27	11.4
Unknown	156		68
Breast Surgery
No_Surgery	167	6.10	90	13.16	< 0.01
Breast-conserving surgery	1561	56.99	246	35.96
Mastectomy	1010	36.87	348	50.88
Surgery (Types_Unknown)	1	0.04	0	0.00
Unknown	5		2
Radiation Therapy
No	1119	41.23	373	54.93	< 0.01
Yes	1595	58.77	306	45.07	< 0.01
Unknown	30		7
Chemotherapy
None	1506	58.28	294	46.08	< 0.01
Single-Agent Chemotherapy	44	1.70	23	3.61
Multiagent Chemotherapy	1034	40.02	321	50.31
Unknown	160		48
Neoadjuvant chemotherapy
No	1884	89.89	447	83.86	< 0.01
Yes	212	10.11	86	16.14	< 0.01
Unknown	91		14
Endocrine Therapy
No	1110	42.53	567	85.91	< 0.01
Yes	1500	57.47	93	14.09	< 0.01
Unknown	134		26

ISSN: 1471-2407