Fig. 1
From: Targeting Ezh2 could overcome docetaxel resistance in prostate cancer cells
Ezh2 was required and sufficient to cause Doc resistance. a Cartoon showing how LNCaP DocR and 22Rv1 DocR cells were established. b, c Confirmation of Doc resistance phenotype of LNCaP cells (b) and 22Rv1 cells c. D. Ezh2 was induced in Doc resistant cells at both protein levels. E-F. Forced expression of Ezh2 was sufficient to cause Doc resistance in LNCaP cells (e) and 22Rv1 cells (f). Ezh2 inhibition by DNZEP could re-sensitize LNCaP DocR cells (g) and 22Rv1 DocR cells (h) to Doc treatment. 2 μM DNZEP was used and GAPDH was used as loading control. P* < 0.05; P** < 0.01