Fig. 5
From: Isocytosine deaminase Vcz as a novel tool for the prodrug cancer therapy
Kaplan-Meier survival analysis of tumorized mice following different treatments. a Subcutaneous GL261 tumors evoked in C57/BL6 mice were treated with co-injections of MSC transduced with Vcz-encoding lentivirus (MSC-Vcz) and different concentrations of 5-FIC, as indicated. In control mice, intratumoral injection of DMSO, MSC-Vcz cells alone (without 5-FIC), 5-FIC alone was used. These control treatment results are shown separately in panel b including additional intratumoral treatments with different concentrations of 5-FU, as indicated. The survival time (number of days) of mice upon different intratumoral treatments and the chi-square test p-values estimated for this experiment, are indicated. The asterisk symbol (*) marks the statistical significance between MSC-Vcz + 5-FIC and control treatment groups, determined by the p-value = 0.035 of the Chi-square test