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Table 2 Spearman’s correlation test for stratification of prognostic subtypes according to the MLVD

From: Tumor-associated lymphangiogenesis predicts unfavorable prognosis of intrahepatic cholangiocarcinoma

MLVD

n (%)

r (95% CI)

P (two-paired)

P value summary

4 to 4

1 (1.3)

NA

NA

NA

4 to 5

7 (8.9)

0.2041 (NA)

0.5714

NS

4 to 6

11 (13.9)

−0.4077 (−0.8166 to 0.2736)

0.1013

NS

4 to 7

16 (20.3)

−0.4604 (−0.7847 to 0.0619)

0.0456

*

4 to 8

19 (24.1)

−0.5844 (− 0.8255 to − 0.1631)

0.0086

**

4 to 9

23 (29.1)

−0.6729 (− 0.8531 to − 0.3494)

0.0004

***

4 to 10

26 (32.9)

−0.6035 (− 0.8074 to − 0.2709)

0.0011

**

4 to 11

27 (34.2)

−0.6182 (− 0.8124 to − 0.3005)

0.0006

***

4 to 12

32 (40.5)

−0.6589 (− 0.8229 to − 0.3936)

< 0.0001

****

4 to 13

37 (46.8)

−0.6647 (− 0.8169 to − 0.4260)

< 0.0001

****

4 to 14

39 (49.4)

−0.6619 (− 0.8119 to − 0.4299)

<  0.0001

****

4 to 15

44 (55.7)

− 0.6436 (− 0.7930 to − 0.4212)

<  0.0001

****

4 to 16

48 (60.8)

− 0.6377 (− 0.7838 to − 0.4248)

< 0.0001

****

4 to 17

50 (63.3)

− 0.6220 (− 0.7709 to − 0.4085)

<  0.0001

****

4 to 18

56 (70.9)

− 0.6630 (− 0.7915 to − 0.4784)

< 0.0001

****

4 to 19

60 (75.9)

−0.6456 (− 0.7759 to − 0.4624)

< 0.0001

****

4 to 20

68 (86.1)

−0.6752 (− 0.7897 to − 0.5152)

< 0.0001

****

4 to 21

69 (87.3)

−0.6811 (− 0.7931 to − 0.5247)

< 0.0001

****

4 to 22

72 (91.1)

−0.6789 (− 0.7895 to − 0.5256)

< 0.0001

****

4 to 23

76 (96.2)

−0.6149 (− 0.7411 to − 0.4466)

< 0.0001

****

4 to 24

76 (96.2)

−0.6149 (− 0.7411 to − 0.4466)

< 0.0001

****

4 to 25

79 (100)

−0.5966 (− 0.7256 to − 0.4271)

< 0.0001

****

  1. Note: Patients censored before 5 years of follow-up were excluded. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001
  2. Abbreviations: MLVD microlymphatic vessel density CI confidence interval. NA not applicable. NS, not significant