Case-control Indian buffet process identifies biomarkers of response to Codrituzumab

BMC Cancer

Table 1 Subpopulations discovered by the Case-Control Indian Buffet Process (C-IBP)

Sub-population	Drug Identifier	F1	F2	F3	Average(*) num. of patients	Mean PFS (month)	Median PFS (month)
1.	0	0	0	0	33.37	3.06	1.65
2.	0	0	1	0	4.07	2.29	2.24
3.	0	1	0	0	17.84	2.72	1.81
4.	0	1	1	0	4.72	7.05	7.18
5.	1	0	0	0	51.52	3.22	2.55
6.	1	0	0	1	16.77	4.17	3.65
7.	1	0	1	0	8.38	1.74	1.33
8.	1	0	1	1	2.07	2.69	2.65
9.	1	1	0	0	29.88	3.36	2.03
10.	1	1	0	1	4.90	4.44	4.34
11.	1	1	1	0	4.53	6.31	5.31
12.	1	1	1	1	1.94	10.04	10.01
Total	120.0	63.82	25.72	25.69	180	3.44	2.04

Three latent features (F1, F2, F3) describe the population in this study, and each subpopulation can have the feature active (1) or inactive (0). Mean PFS was used as meaningful clinical endpoint. (*) Average number of patients is reported since the C-IBP is a probabilistic method that allows for soft-clustering of the patients (each patient belong to a subpopulation with a certain probability)

ISSN: 1471-2407