Fig. 3
In vivo suppression of phospho-ERK signalling in an MM415 murine xenograft model. a Normalised total pERK1/2, b pERK1 (T202, 44 kDa) and (c) pERK2 (Y204, 42 kDa) levels (mean ± SEM) in MM415 (Q61L) tumour xenografts from NSG immuno-deficient mice following PPL-008C treatment, at multiple time points, with either 25 mg/kg or 100 mg/kg doses (control N = 3, treated N = 4, * P < 0.05). Control mice were treated with a 5% dextrose in dH2O solution and PPL-008C was administered via subcutaneous injection at the site of tumour. Representative pERK1/2 and GAPDH immunoblot examples shown below (a)