Table 1 Genes incorporated in the CAGP
Number of genes in common [number of gene lists containing these genes] | Genes in CAGP | Seven different gene lists with the number of contributing genes (n = total number of genes in the list) | ||||||
|---|---|---|---|---|---|---|---|---|
Easton et al. (n = 119) | Rahman et al. (n = 114) | BROCA v6 (n = 61) | GeneRead v2 (Qiagen) (n = 143) | Kanchi et al. (n = 47) | Wood et al. (n = 178) | FaCD (n = 319) | ||
8 [7] | ATM, BRCA1, BRCA2, BRIP1, CHEK2, MLH1, PALB2, RAD51C | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
17 [6] | BLM, ERCC4, ERCC5, FANCA, FANCC, FANCG, MSH2, MSH6, MUTYH, NBN, PMS2, POLD1, POLE, RAD51D, SLX4, TP53, XPC | 17 | 16 | 10 | 17 | 8 | 17 | 17 |
36 [5] | APC, ATR, BAP1, BMPR1A, CDH1, CDK4, CDKN2A, DDB2, ERCC2, ERCC3, FANCB, FANCD2, FANCE, FANCF, FANCI, FANCL, FANCM, FH, FLCN, MEN1, MRE11A, NF1, PRKAR1A, PTCH1, PTEN, RB1, RECQL4, RET, SDHB, SDHC, SDHD, SMAD4, STK11, VHL, WRN, XPA | 36 | 27 | 23 | 36 | 8 | 15 | 35 |
36 [4] | ALK, AXIN2, BARD1, BUB1B, CDC73, CHEK1, CYLD, DICER1, DIS3L2, EPCAM, EXT1, EXT2, GATA2, GPC3, HRAS, KIT, MAX, MET, NF2, PALLD, PIK3CA, POLH, PRSS1, RAD51B, RHBDF2, RUNX1, SBDS, SDHAF2, SMARCA4, SMARCB1, SUFU, TMEM127, TSC1, TSC2, WT1, XRCC2 | 33 | 29 | 10 | 34 | 0 | 4 | 34 |
24 [3] | AKT1, CDKN1B, CEBPA, CTNNA1, DKC1, EGFR, EXO1, FAH, GALNT12, GEN1, GREM1, HFE, HOXB13, MLH3, PDGFRA, PHOX2B, RAD50, RAD51, SDHA, TERT, TGFBR1, UROD, WAS, XRCC3 | 12 | 13 | 6 | 15 | 2 | 6 | 18 |
56 [2] | AIP, ANTXR1, ANTXR2, ATRIP, CBL, CD96, CDKN1C, CEP57, COL7A1, CTNNB1, EHBP1, ELANE, EME1, EPHB2, ERCC1, ERCC6, ESCO2, FAM175A, FAS, GBA, GJB2, GLI3, GLMN, HMBS, HNF1A, KDR, LIG4, LYST, MC1R, MITF, MTAP, NSD1, PDE11A, PMS1, POLI, POLK, PRF1, PTCH2, PTPN11, REV3L, RINT1, RMRP, RNASEL, RPA1, RPA2, RPA4, RSPO1, SERPINA1, SH2D1A, SOS1, SRY, STAT3, TINF2, TP53BP1, TRIM37, UNG | 10 | 16 | 2 | 21 | 9 | 14 | 40 |
315 [1] | ABCB11, ABCC11, ACVRL1, ADA, ADH1C, AFP, AICDA, AIRE, AKR1A1, ALKBH2, ALKBH3, AMH, AP3B1, APEX1, APEX2, APITD1, APLF, APTX, AR, ARL6, ASCC1, ATP2C1, ATP7B, ATP8B1, AXIN1, BBS1, BBS10, BBS12, BBS2, BBS4, BBS5, BBS7, BBS9, BLOC1S3, BRAF, BTK, CCM2, CCNH, CD40, CD40LG, CDK7, CDKN1A, CDKN2B, CDKN2C, CDKN2D, CETN2, CFTR, CHAF1A, CLK2, COL17A1, COL4A5, COL4A6, CREBBP, CSH1, CXCR4, CYP11B1, CYP11B2, CYP1A1, CYP21A2, CYP2E1, CYP7A1, DAPK1, DCLRE1A, DCLRE1B, DCLRE1C, DDB1, DHCR7, DMC1, DNAAF1, DNAAF2, DNAH11, DNAH5, DNAI1, DNAI2, DOCK8, DTNBP1, DUT, ELAC2, EME2, ENDOV, ENG, EP300, EPAS1, ERCC8, EZH2, F12, FAAP20, FAAP24, FAN1, FEN1, FGFR2, FGFR3, FHIT, FLG, FLT4, FMR1, FOXC2, FOXI1, FSHR, G6PC, GALT, GBE1, GNAS, GRB10, GSTM1, GSTT1, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, H19, H2AFX, HAX1, HBB, HELQ, HES1, HLA-A, HLA-B, HLA-DQB1, HLA-DRA, HLA-DRB1, HLTF, HMGA2, HNF1B, HPS1, HPS3, HPS4, HPS5, HPS6, HUS1, IDH1, IDH2, IL1RN, IL2RG, ITK, JAG1, JAK2, KCNQ1OT1, KIF1B, KITLG, KLHDC8B, KRAS, KRIT1, KRT17, LHCGR, LIG1, LIG3, LMNA, LMX1B, LZTR1, MAD2L2, MAP2K1, MAP2K2, MBD4, MDC1, MGMT, MKKS, MMS19, MNAT1, MNX1, MPG, MPLKIP, MSH3, MSH4, MSH5, MSMB, MSR1, MUS81, MYH8, MYH9, NABP2, NAT2, NDN, NDUFA13, NEIL1, NEIL2, NEIL3, NHEJ1, NME8, NOTCH2, NRAS, NTHL1, NTRK1, NUDT1, OCA2, OGG1, PARP1, PARP2, PARP3, PAX5, PAX6, PCA3, PCNA, PDCD10, PDK1, PDK2, PDPK1, PER1, PMS2CL, PMS2P3, PNKP, POLB, POLG, POLL, POLM, POLN, POLQ, POT1, POU6F2, PPM1D, PPOX, PRKDC, PRPF19, PTH1R, PTPRJ, RAD1, RAD17, RAD18, RAD23A, RAD23B, RAD52, RAD54B, RAD54L, RAD9A, RAF1, RAG1, RAG2, RBBP8, RDM1, RECQL, RECQL5, REV1, RGS17, RIF1, RMI1, RMI2, RNF139, RNF168, RNF4, RNF8, RPA3, RPS19, RPS20, RRM2B, RSPH4A, RSPH9, RTEL1, SART3, SERPING1, SETBP1, SETMAR, SFTPA2, SH3BP2, SHFM1, SHOX, SHPRH, SIL1, SLC25A13, SLC26A4, SLC37A4, SLX1A, SLX1B, SMARCAL1, SMARCE1, SMC1A, SMC3, SMUG1, SNRPN, SPINK1, SPO11, SPRED1, SPRTN, SPRY4, SQSTM1, STS, STX11, T, TDG, TDP1, TDP2, TELO2, TERC, TGFBR2, TMC6, TMC8, TNF, TNFRSF11A, TNFRSF13B, TOP3A, TOP3B, TOPBP1, TP63, TREX1, TREX2, TRIM32, TRPS1, TTC8, TWIST1, TYR, TYRP1, UBE2A, UBE2B, UBE2N, UBE2V2, UNC13D, USP1, UVSSA, WDR48, XAB2, XIAP, XRCC1, XRCC4, XRCC5, XRCC6 | 3 | 5 | 2 | 12 | 12 | 114 | 167 |