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Fig. 3 | BMC Cancer

Fig. 3

From: Nodal induces apoptosis and inhibits proliferation in ovarian endometriosis-clear cell carcinoma lesions

Fig. 3

Relationship of Nodal with GSK-3β in endometriosis-OCCCa /OEmCa. a Upper: structure of Nodal protein showing the position of a putative GSK-3β phosphorylation motif. The corresponding constructs that were used in this study are also shown. WT, wild-type; 2TA, mutant type. Lower: western blot analysis for the indicated proteins after treatment of Ishikawa cells stably overexpressing wild-type and mutant type 2TA Nodal with 40 mM LiCl for 24 h with or without 10 μM MG132 for 5 h. b Staining by hematoxylin and eosin (HE) and IHC for Nodal and pGSK-3β in endometriosis, OCCCa, and OEmCa. Insets show the magnified views of the boxed areas. Original magnification, × 100 and × 400 (inset). c. IHC scores for pGSK-3β in endometriosis-OCCCa (left) and endometriosis-OEmCa (right). The data shown are means  ± SDs. d Correlation between Nodal and pGSK-3β scores in a combination of endometriosis and OCCCa (left) or OEmCa (right)

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BMC Cancer

ISSN: 1471-2407

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