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Fig. 3 | BMC Cancer

Fig. 3

From: Nonsynonymous, synonymous and nonsense mutations in human cancer-related genes undergo stronger purifying selections than expectation

Fig. 3

Purifying selection on the nonsynonymous as well as the synonymous SNPs in cancer-related genes. a Comparison between the nonsynonymous to synonymous ratio (nsy/syn) of cancer-related genes and other genes. P-value was calculated using Wilcoxon rank sum test. b Comparison between the pooled nsy/syn ratio of cancer-related genes and other genes. P-value was calculated using Fisher’s exact test. c Conservation level (phyloP score) of nonsynonymous and synonymous SNPs in cancer-related genes and other genes. P-values were calculated using Wilcoxon rank sum tests. d Fractions of conserved orthologous sites in mouse genome. P-values were calculated using Fisher’s exact tests. “onco” denotes cancer-related genes; “non-onco” denotes other genes

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BMC Cancer

ISSN: 1471-2407

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