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Table 4 Multivariate analysis of PFS and OS in paired patients (N = 83)

From: Differential expressions of PD-1, PD-L1 and PD-L2 between primary and metastatic sites in renal cell carcinoma

 

Cox’s regression for PFS

Cox’s regression for OS

HR

95% Cl

P value

PA

HR

95% Cl

P value

PA

ISUP

  ≥ 3 vs < 3

2.18

0.89–5.31

0.09

0.546

12.1

0.99–147.1

0.05

0.576

Nephrectomy

 Yes vs No

    

0.03

0.004–0.25

0.001

0.525

IMDC

   

0.615

   

0.618

 Low

Ref.

Ref.

0.04

 

Ref.

Ref.

0.17

 

 Intermediate

1.12

0.5–2.51

0.78

 

1.21

0.35–4.18

0.8

 

 High

2.54

1.08–5.97

0.03

 

2.71

0.76–9.58

0.12

 

Laboratory parameters

 WBC

    

1.02

1.01–1.04

0.002

0.624

 Na

    

0.93

0.82–1.06

0.26

0.556

PD-L1 positive (P)a

    

0.98

0.35–2.77

0.97

0.583

Cox model without PD-L1

       

0.754

Cox model with PD-L1

       

0.757

  1. aP, Primary tumor
  2. Abbreviations: ISUP International Society of Urological Pathology, IMDC International Metastatic Renal-Cell Carcinoma Database Consortium
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