Elevated X-linked inhibitor of apoptosis protein (XIAP) expression uncovers detrimental prognosis in subgroups of neoadjuvant treated and T-cell rich esophageal adenocarcinoma

Table 1 Basic clinical and demographic characteristics of studied patients.

	total		XIAP low		XIAP high		p
	n	%	n	%	n	%
number of patients	311	100	267	85.9	44	14.1
sex
female	32	10.3	29	90.6	3	9.4	0.593
male	279	89.7	238	85.3	41	14.7
age at diagnosis			62.1		66.3		0.032
initial T stage (^a)
pT1	25	8.1	21	84	4	16	0.151
pT2	29	9.4	29	100	0	0
pT3	250	80.6	211	84.4	39	15.6
pT4	6	1.9	5	83.3	1	16.7
initial N stage (^a)
pN0	126	40.6	104	82.5	22	17.5	0.260
pN1	113	36.5	101	89.4	12	10.6
pN2	36	11.6	29	80.6	7	19.4
pN3	35	11.3	32	91.4	3	8.6
Grading
G1	3	1.4	3	100	0	0	0.539
G2	136	62.4	112	82.4	24	17.6
G3	78	35.8	69	88.5	9	11.5
G4	1	0.5	1	100	0	0
R status (^c)
R0	206	66.2	175	85	31	15	0.424
R1	16	5.1	14	87.5	2	12.5
R2	2	0.6	1	50	1	50
neoadjuvant therapy (^b)
yes	185	60.3	165	89.2	20	10.8	0.064
no	122	39.7	99	81.1	23	18.9
type of neoadj. Therapy (‘)
Rctx	107	93	86	80.4	21	19.6	0.620
Ctx	8	7	7	87.5	1	12.5

^a, ^b,^c,’ indicate missing clinical information for the respective category (^a: n = 1 missing, ^b: n = 4 missing, ^c n = 87 missing, ‘=74 missing)

ISSN: 1471-2407