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Fig. 2 | BMC Cancer

Fig. 2

From: Vaccination with synthetic long peptide formulated with CpG in an oil-in-water emulsion induces robust E7-specific CD8 T cell responses and TC-1 tumor eradication

Fig. 2

E7 SLP + CpG + o/w emulsion superior induction of antigen specific CD8 T cells. Mice (n = 5) were immunized s.c. on day 0 and 21 with 5 μg E7 SLP +/− 20 μg CpG, 25 μg MPL, 50 μg poly(I:C), or 20 μg R848, and formulated in either w/o emulsion or o/w emulsion. Splenocytes were isolated on day 28 and stained with E7-specific dextramer for FACS analysis. a Representative dot plots of E7-specific dextramer staining of CD8 T cells. b The percentage of E7-specific dextramer+ CD8 T cells is presented for each vaccine condition. Two-sided hypothesis test for comparisons using one-way ANOVA model ***, p < 0.001

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BMC Cancer

ISSN: 1471-2407

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