Subgroup-specific prognostic signaling and metabolic pathways in pediatric medulloblastoma

BMC Cancer

Table 1 Top five prognosis-related canonical pathways in SHH subgroup

Database	Name of gene set (GSEA)	Exploratory dataset (n = 85)		Validation dataset (n = 36)		1000 bootstrap datasets (n = 121)	Representative core genes**
Database	Name of gene set (GSEA)	HR*	p-value	HR*	p-value	% of p-value < 0.05	Representative core genes**
PID	p53 pathway	4.59	< 0.0001	3.19	0.127	100.0	TRIM28,CCNA2,ABL1,SETD7,CSE1L,HIPK2,RPL11
	PLK1 signaling events	2.02	0.0035	1.72	0.093	95.6	NUDC,PLK1,AURKA,TPX2,BUB1,CDC20,TPT1, BORA,CENPE,KIF20A,PRC1,CCNB1,CDC25C,WEE1,ECT2
	Aurora B signaling	1.73	0.0155	1.84	0.086	91.9	CDCA8,SMC2,AURKA,KIF2C,BUB1,RACGAP1, BIRC5,NCAPD2,KIF23,KIF20A,NCAPH
	FOXM1 transcription factor network	1.89	0.0119	1.75	0.109	90.8	PLK1,CCNA2,FOXM1,BIRC5,NEK2,ETV5, CCNB1,CENPF,BRCA2,CDK4,CHEK2,CKS1B
KEGG	Alanine aspartate and glutamate metabolism	4.85	0.0001	1.76	0.432	94.3	PPAT,GLUD1,GPT2
	RNA polymerase	1.96	0.0032	2.36	0.022	93.3	POLR2E,POLR3H,POLR2B,POLR2J,POLR2D, POLR3K,POLR1B,POLR1A
	Basal transcription factors	2.48	0.0002	1.49	0.580	91.6	GTF2F1,TAF4,GTF2A1L,TAF11
BIOCARTA	Cyclins and Cell Cycle Regulation	1.92	0.0127	3.17	0.029	91.7	CCNA1,CDKN2C,CCNB1,CDC25A,TFDP1,CDK4
	Proteasome Complex	1.71	0.0053	1.57	0.274	79.1	PSMB7,PSMA7,PSMD14,PSMB2

* Hazard ratio per 0.1 increment in average relative expression of core genes
** Representative core genes are significantly associated with overall survival (p-value < 0.05) in Cox regression analysis with all samples

ISSN: 1471-2407