From: Subgroup-specific prognostic signaling and metabolic pathways in pediatric medulloblastoma
Database | Name of gene set (GSEA) | Exploratory dataset(n = 177) | Validation dataset (n = 76) | 1000 bootstrapped datasets (n = 253) | Representative core genes** | ||
---|---|---|---|---|---|---|---|
HR* | p-value | HR* | p-value | % of p-value < 0.05 | |||
PID | Notch-mediated HES/HEY network | 6.49 | < 0.0001 | 3.35 | 0.009 | 100.0 | HDAC1,NOTCH1,GATA4,HEY1,TCF3,PARP1,RBBP8,E2F1 |
TNF receptor signaling pathway | 5.31 | < 0.0001 | 5.54 | 0.000 | 100.0 | FADD,TNFRSF1A,TNFRSF1B,CAV1,IKBKB,GNB2L1,NFKB1 | |
Validated nuclear estrogen receptor α network | 8.13 | < 0.0001 | 5.94 | 0.006 | 99.9 | MYC,HDAC1,XBP1,TRIM59,CCND1,LCOR,UBE2M | |
EPO signaling pathway | 3.50 | < 0.0001 | 3.12 | 0.012 | 99.9 | CBL,CRKL,INPP5D,NFKB1 | |
Fc-epsilon receptor I signaling in mast cells | 4.09 | < 0.0001 | 2.84 | 0.018 | 99.9 | CBL,GAB2,INPP5D,FCGR2B,IKBKB,NFKB1,FOS | |
KEGG | Acute myeloid leukemia | 4.85 | < 0.0001 | 3.84 | 0.005 | 100.0 | MYC,AKT3,EIF4EBP1,IKBKB,NFKB1,CCND1 |
Dorso ventral axis formation | 2.68 | 0.0004 | 2.82 | 0.026 | 99.5 | NOTCH1,ETS2,NOTCH2 | |
Antigen processing and presentation | 1.71 | 0.0068 | 2.10 | 0.004 | 95.5 | B2M,HSPA1A,HLA-F,TAP2,RFXANK,CD74,PDIA3,HLA-DMA | |
Nucleotide excision repair | 2.22 | 0.0007 | 1.40 | 0.377 | 93.2 | DDB1,POLD4,POLE2,POLE4 | |
One carbon pool by folate | 2.09 | < 0.0001 | 1.13 | 0.635 | 92.7 | GART,MTHFD2L,MTHFD2,TYMS,DHFR | |
BIOCARTA | Keratinocyte Differentiation | 3.29 | 0.0001 | 3.32 | 0.002 | 100.0 | PRKCD,ETS2,TNFRSF1A,TNFRSF1B,IKBKB,NFKB1,FOS |
NF-kB Signaling Pathway | 2.55 | 0.0001 | 2.33 | 0.004 | 100.0 | MYD88,FADD,TNFRSF1A,TNFRSF1B,IKBKB,IL1R1,NFKB1 | |
HIV-I Nef: negative effector of Fas and TNF | 4.71 | < 0.0001 | 3.15 | 0.011 | 99.9 | PRKCD,FADD,TNFRSF1A,TNFRSF1B,PRKDC,PSEN2, PARP1,NFKB1 | |
NF-kB activation by Nontypeable H. influenzae | 5.83 | < 0.0001 | 3.61 | 0.016 | 99.8 | MYD88,IKBKB,SMAD3,NFKB1 | |
Cell Cycle: G1/S Check Point | 2.64 | 0.0001 | 3.54 | 0.009 | 99.8 | CDC25A,HDAC1,TGFB1,CDKN1A,DHFR,CDK1,SMAD3, CDK2,CCND1,E2F1 |