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Fig. 2 | BMC Cancer

Fig. 2

From: Monospecific antibody targeting of CDH11 inhibits epithelial-to-mesenchymal transition and represses cancer stem cell-like phenotype by up-regulating miR-335 in metastatic breast cancer, in vitro and in vivo

Fig. 2

Cancer-associated fibroblasts (CAFs)-induced CDH11 overexpression promotes the metastatic potential of breast cancer cells. a Graphical representation of the differential expression of CDH11, vimentin and CTNNB1 in MCF7 (left panel) or MDA-MB-231 (right panel) cells, co-cultured with CAFs, compared to the independently cultured cells. b Photo-images with densitometry quantification from western blot analyses show the effect of CAF-co-culture on the expression of E-cadherin, CDH11, vimentin, β-catenin, FN, and EZH2 proteins in MCF7 or MDA-MB-231 cells. CDH11-enriched CAFs enhanced the (c) migratory and (d) invasive abilities MCF7 or MDA-MB-231 cells. CAF, cancer-associated fibroblast; CTNNB1, β-catenin; VIM, vimentin; +CAF, CAF co-cultured; FN, fibronectin; *p < 0.05; **p < 0.01; ***p < 0.001

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BMC Cancer

ISSN: 1471-2407

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