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Fig. 4 | BMC Cancer

Fig. 4

From: Monospecific antibody targeting of CDH11 inhibits epithelial-to-mesenchymal transition and represses cancer stem cell-like phenotype by up-regulating miR-335 in metastatic breast cancer, in vitro and in vivo

Fig. 4

MiR-335 directly targets CDH11 and reverses CDH11-induced cancer-related biological activities. a Graphical representation of the differential expression of miR-335 in parental MCF7 or MDA-MB-231 cells and their mammospheres. b Histograms showing the effect of miR-335 mimic or inhibitor on the mRNA expression of CDH11, vimentin and β-catenin in MCF7 or MDA-MB-231 cells. c Photo-images (left panel) and histograms (right panel) showing the effect of miR-335 mimic or inhibitor on the mRNA expression of CDH11, vimentin and β-catenin in MCF7 or MDA-MB-231 cells, compared to control. d The effect of miR-335 mimic or inhibitor on mammosphere formation, compared to the control group. e Western blot photo-images of the effect of miR-335 mimic or inhibitor on the protein expression of CDH11 and β-catenin, compared to control. *p < 0.05; **p < 0.01; ***p < 0.001

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BMC Cancer

ISSN: 1471-2407

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