Fig. 1

Mouse number and measurement accuracy of categorical responses defined by the mRECIST criteria. (a-c): individual mouse response and majority response in PDX (a), CDX (b) and syngeneic models (c), x axis is the number of majority response from 4 response categories (CR: complete response, PR: partial response, SD: stable disease, PD: progressive disease.), y axis is the percentage of individual mouse response relative to the majority (average ± s.d.). There are 26,127 mice in 2,883 unique treatment PDX models, 11,139 mice in 1,219 unique treatment CDX models, and 5,945 mice in 637 unique treatment syngeneic models. Each unique treatment model had at least 8 mice. (d-g): measurement accuracy increases with number of mice for PDX (d), CDX (e) and syngeneic models (f). For each unique treatment model, the majority response of n (n = 1, 3, 5, 7 in x axis) randomly sampled mice was obtained to see if it agreed with the actual majority response. The procedure was repeated 1,000 times to obtain the accuracy—percentage of times (average ± s.d.) that they agreed—for the 4 response categories, whose unweighted average is shown in (g). (h-j): Venn diagram showing the overlap of unique treatment PDX models classified as objective response by 4 categorical methods in PDX (h), CDX (i), and syngeneic models (j). Objective response is OR in the 3-cat method, CR + PR in the mRECIST and RECIST methods, MCR + CR + PR in the 5-cat method