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Table 2 Tumor characteristics and treatment modalities of the entire cohort according to genotype (n = 180)

From: Hepatitis C virus genotype affects survival in patients with hepatocellular carcinoma

 

Genotype 1 (n = 86)

Genotype 2 (n = 78)

Genotype 3 (n = 16)

AFP, ng/mL

19.9 (9.3–93.2)

41.8 (8.4–100.2) b

21.7 (7.3–72.9)

Within Milan criteria

53 (61.6%)

52 (66.7%)

8 (50.0%)

Malignant vascular invasion

7 (8.1%)

4 (5.1%) b

4 (25.0%)

Extrahepatic metastasis

3 (3.5%)

1 (1.3%)

2 (12.5%)

HCC nodules

 1

47 (54.7%)

48 (61.5%)

5 (31.3%)

 2~3

19 (22.1%)

21 (26.9%)

6 (37.5%)

 ≥ 4

20 (23.3%)

9 (11.5%)

5 (31.3%)

Largest tumor size

 < 2 cm

27 (30.7%)

21 (26.9%)

6 (37.5%)

 2 ~  5 cm

41 (47.7%)

45 (57.7%)

5 (31.3%)

 > 5 cm

18 (20.9%)

12 (15.4%)

5 (31.3%)

BCLC b c

 0

15 (17.4%)

10 (12.8%)

1 (6.3%)

 A

41 (47.7%)

46 (59.0%)

7 (43.8%)

 B

19 (22.1%)

14 (17.9%)

1 (6.3%)

 C

10 (11.6%)

5 (6.4%)

5 (31.3%)

 D

1 (1.2%)

3 (3.8%)

2 (12.5%)

mUICC b c

 1

15 (17.4%)

13 (16.7%)

2 (12.5%)

 2

39 (45.3%)

39 (50.0%)

8 (50.0%)

 3

22 (25.6%)

24 (30.8%)

4 (25.0%)

 4

10 (11.6%)

2 (2.6%)

2 (12.5%)

Treatment modality

 Resection

17 (19.8%)

23 (29.5%)

1 (6.3%)

 RFA

23 (26.7%)

19 (24.4%) b

0 c

 TACE

58 (67.4%) a

40 (51.3%)

11 (68.8%)

 PEI

1 (1.2%)

1 (1.3%)

0

 Radiotherapy

10 (11.6%)

6 (7.7%)

1 (6.3%)

 Systemic chemotherapy

2 (2.3%)

1 (1.3%)

0

 Sorafenib

4 (4.7%)

1 (1.3%)

1 (6.3%)

 Liver transplantation

0

1 (1.3%)

0

 No Treatment

9 (10.5%)

12 (15.4%)

2 (12.5%)

Curative Treatment (Initial)

26 (33.7%)

36 (46.2%) b

1 (6.3%) c

Recurrence after curative treatment (n = 66)

20 (69.0%)

21 (58.3%)

1 (100%)

Decompensation

47 (54.7%) a

22 (28.6%) b

13 (81.3%)

Death

49 (57.0%) a

29 (37.2%) b

11 (68.8%)

  1. Abbreviation: AFP Alpha-fetoprotein, BCLC Barcelona Clinic Liver Cancer, HCC Hepatocellular carcinoma, RFA Radiofrequency ablation, TACE, Transarterial chemoembolization, PEI Percutaneous ethanol injection
  2. a p < 0.05 genotype 1 vs genotype 2, b p < 0.05 genotype 2 vs genotype 3, c p < 0.05 genotype 1 vs genotype 3 using the Mann-Whitney U-test and Chi-squared test
  3. Data are presented as the median (interquartile range) for continuous data and percentages for categorical data