Table 1 Demographic and clinical characteristics of patients
Demographic and clinical characteristic | No. of patients (n = 85) |
|---|---|
Age, year | |
 Mean (+ SD) | 59.1 + 10.8 |
Gender, No. (%) | |
 Female | 47 (55.3) |
 Male | 38 (44.7) |
Ethnicity, No. (%) | |
 Chinese | 63 (74.1) |
 Non-Chinese (Malay and Indian) | 22 (25.9) |
Smoking history, No. (%) | |
 Never smoker | 67 (78.8) |
 Previous or current smoker | 18 (21.2) |
ECOG performance status at diagnosis, No. (%) | |
 ECOG 0–1 | 69 (81.2) |
 ECOG 2–4 | 16 (18.8) |
Tumor histology, No. (%) | |
 Adenocarcinoma | 82 (96.5) |
 Squamous cell carcinoma | 3 (3.5) |
Tumor stage, No. (%) | |
 IIIB | 4 (4.7) |
 IV | 81 (95.3) |
Symptomatic baseline brain metastases, No. (%) | |
 No | 60 (70.6) |
 Yes | 25 (29.4) |
  -Parenchymal metastases | 16 (64.0) |
  -Leptomeningeal metastases | 7 (28.0) |
  -Both parenchymal and leptomeningeal metastases | 2 (8.0) |
Abnormal organ function, No. (%) | |
 No | 70 (82.4) |
 Yes | 15 (17.6) |
  -Blood | 5 (33.3) |
  -Renal | 9 (60.0) |
  -Liver | 2 (13.3) |
EGFR mutation subtype, No. (%) | |
 Exon 19 deletion | 68 (80.0) |
 Exon 21 L858R point mutation | 11 (12.9) |
 Rare or complex mutations | 6 (7.1) |
  -Exon 18 G719X | 2 (33.1) |
  -Exon 18 G719X and exon 20 S768I | 1 (16.7) |
  -Exon 18 G719X and exon 20 T790 M | 1 (16.7) |
  -Exon 19 deletion and exon 20 insertion | 1 (16.7) |
  -Exon 20 insertion | 1 (16.7) |