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Fig. 1 | BMC Cancer

Fig. 1

From: GX15–070 (Obatoclax), a Bcl-2 family proteins inhibitor engenders apoptosis and pro-survival autophagy and increases Chemosensitivity in neuroblastoma

Fig. 1

a Basal level expression of important pro and antiapoptotic BCL-2 family proteins in human neuroblastoma. β-actin served as loading control. b. The effect of GX 15–070 used in monotherapy in NB cell viability in vitro. IGR-NB8, IGR-91, NB-10, SK-N-DZ and SK-N-FI cells treated 24 and 48 h with increasing concentrations of GX 15–070 (0.078 μM, 0.15 μM, 0.3 μM, 0.6 μM, and 5 μM).were added to the medium for 24 and 48 h and cell viability determined by the standard methyl-thiazoldiphenyl tetrazolium (MTT) assay. Each value represents the mean ± SEM (n = 3)

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BMC Cancer

ISSN: 1471-2407

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