Dual oxidase 1 and NADPH oxidase 2 exert favorable effects in cervical cancer patients by activating immune response

Table 3 Hallmark pathways of DUOX1 and NOX2 in cervical cancer

Term	Size	ES	NES	NOM p-val
DUOX1 – Hallmark pathways up
HALLMARK_INTERFERON_ALPHA_RESPONSE	97	0.57	2.17	0.00
HALLMARK_INTERFERON_GAMMA_RESPONSE	199	0.44	1.85	0.00
HALLMARK_ESTROGEN_RESPONSE_EARLY	197	0.39	1.63	0.00
HALLMARK_ESTROGEN_RESPONSE_LATE	200	0.37	1.56	0.00
HALLMARK_INFLAMMATORY_RESPONSE	200	0.29	1.19	0.09
HALLMARK_TNFA_SIGNALING_VIA_NFKB	200	0.27	1.12	0.17
DUOX1 – Hallmark pathways down
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	199	−0.59	−2.43	0.00
HALLMARK_ANGIOGENESIS	36	−0.51	−1.62	0.01
HALLMARK_HEDGEHOG_SIGNALING	36	−0.47	−1.49	0.04
HALLMARK_KRAS_SIGNALING_UP	200	−0.34	−1.41	0.01
HALLMARK_WNT_BETA_CATENIN_SIGNALING	42	−0.39	− 1.29	0.11
HALLMARK_APICAL_JUNCTION	200	−0.30	−1.27	0.03
NOX2– Hallmark pathways up
HALLMARK_INTERFERON_GAMMA_RESPONSE	199	0.80	2.93	0.00
HALLMARK_INFLAMMATORY_RESPONSE	200	0.77	2.77	0.00
HALLMARK_INTERFERON_ALPHA_RESPONSE	97	0.81	2.69	0.00
HALLMARK_IL6_JAK_STAT3_SIGNALING	87	0.76	2.47	0.00
HALLMARK_IL2_STAT5_SIGNALING	198	0.63	2.30	0.00
HALLMARK_TNFA_SIGNALING_VIA_NFKB	200	0.63	2.29	0.00
NOX2– Hallmark pathways down
HALLMARK_GLYCOLYSIS	199	−0.36	−1.50	0.00
HALLMARK_NOTCH_SIGNALING	32	−0.34	−1.05	0.37
HALLMARK_HEDGEHOG_SIGNALING	36	−0.28	−0.89	0.65
HALLMARK_FATTY_ACID_METABOLISM	156	−0.22	−0.88	0.80
HALLMARK_PROTEIN_SECRETION	96	−0.22	−0.83	0.89
HALLMARK_G2M_CHECKPOINT	194	−0.12	−0.52	1.00

ISSN: 1471-2407