Table 2 Relationship between SMAD4 expression and clinic pathological features
Group | SMAD4 expression | χ2 | p-value | |
|---|---|---|---|---|
Intact SMAD4 | Lost SMAD4 | |||
Sex | ||||
 Male | 8 (34.78%) | 25 (34.7%) | <0.001 | 1.000 |
 Female | 15 (65.22%) | 47 (65.3) |  |  |
Age (year) | ||||
 <60 | 11 (47.8%) | 19 (26.4%) | 3.708 | 0.072 |
 ≥60 | 12 (52.2%) | 53 (73.6%) |  |  |
Tumor diameter (cm) | ||||
 <3 | 11 (47.8%) | 15 (20.8%) | 6.389 | 0.016 |
 ≥3 | 12 (52.2%) | 57 (79.2%) |  |  |
TNM tumor staging | ||||
 IA~IIA | 21 (91.3%) | 46 (63.9%) | 6.303 | 0.016 |
 IIB~IV | 2 (8.7%) | 26 (36.1%) |  |  |
Lymphatic invasion | ||||
 Yes | 2 (8.7%) | 70 (97.2%) | 74.451 | <0.001 |
 No | 21 (91.3%) | 2 (2.8%) |  |  |
Tumor location | ||||
 Head | 11 (47.8%) | 47 (65.3%) | 2.233 | 0.149 |
 Body and tail | 12 (52.2%) | 25 (34.7%) |  |  |
Differentiation | ||||
 High and middle differentiation | 12 (52.2%) | 19 (26.4%) | 5.272 | 0.039 |
 Poorly differeftiation | 11 (47.8%) | 53 (73.6%) |  |  |
Perineural invasion | ||||
 Yes | 9 (39.1%) | 22 (30.6%) | 0.583 | 0.610 |
 No | 14 (60.9%) | 50 (69.4%) |  |  |