Toxicity Category | Grade 1 or 2 | Grade 3 or 4 | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Triplet | Doublet | Â | Â | Triplet | Doublet | Â | Â | |||||||||
T | Total | % | T | Total | % | RR | 95%CI | T | Total | % | T | Total | % | RR | 95%CI | |
Hematological | ||||||||||||||||
 Neutropenia | 131 | 748 | 18 | 184 | 651 | 28 | 0.62 | 0.51-0.76 | 682 | 1234 | 55 | 368 | 970 | 38 | 1.46 | 1.32-1.60 |
 Leucopenia | 291 | 680 | 42 | 277 | 684 | 40 | 1.06 | 0.93-1.20 | 474 | 1102 | 43 | 252 | 885 | 28 | 1.51 | 1.33-1.71 |
 Anemia | 498 | 925 | 53 | 454 | 924 | 49 | 1.10 | 1.00-1.20 | 111 | 784 | 14 | 123 | 682 | 18 | 0.79 | 0.62-0.99 |
 Thrombocytopenia | 151 | 846 | 18 | 162 | 848 | 19 | 0.93 | 0.76-1.14 | 113 | 1181 | 9 | 119 | 934 | 12 | 0.75 | 0.59-0.96 |
 Febrile neutropenia | 79 | 254 | 31 | 46 | 214 | 21 | 1.45 | 1.06-1.98 | 109 | 1026 | 10 | 44 | 774 | 6 | 1.87 | 1.33-2.62 |
Non-hematological | ||||||||||||||||
 Nausea | 358 | 584 | 61 | 353 | 491 | 71 | 0.85 | 0.78-0.93 | 115 | 1130 | 10 | 118 | 900 | 13 | 0.78 | 0.61-0.99 |
 Vomiting | 295 | 716 | 41 | 275 | 622 | 44 | 0.93 | 0.82-1.06 | 74 | 795 | 9 | 70 | 618 | 11 | 0.82 | 0.60-1.12 |
 Diarrhea | 343 | 748 | 46 | 201 | 651 | 31 | 1.49 | 1.29-1.71 | 125 | 1590 | 8 | 62 | 1323 | 5 | 1.68 | 1.25-2.25 |
 Stomatitis | 254 | 716 | 35 | 165 | 622 | 27 | 1.34 | 1.14-1.58 | 151 | 1594 | 9 | 96 | 923 | 10 | 0.91 | 0.71-1.16 |
 Anorexia | 150 | 467 | 32 | 138 | 376 | 36 | 0.88 | 0.73-1.06 | 57 | 546 | 10 | 41 | 452 | 9 | 1.15 | 0.79-1.69 |
 Fatigue | 175 | 376 | 46 | 132 | 283 | 47 | 1.00 | 0.85-1.18 | 52 | 376 | 14 | 35 | 283 | 12 | 1.12 | 0.75-1.67 |
 Hand foot yndrome | 45 | 259 | 17 | 32 | 168 | 19 | 0.91 | 0.61-1.37 | 17 | 376 | 5 | 7 | 237 | 3 | 1.53 | 0.64-3.64 |
 Sensory europathy | 227 | 597 | 38 | 162 | 507 | 32 | 1.19 | 1.01-1.40 | 75 | 1021 | 7 | 49 | 805 | 6 | 1.21 | 0.85-1.71 |
 Alopecia | 83 | 242 | 34 | 39 | 148 | 26 | 1.30 | 0.94-1.97 | 87 | 538 | 16 | 45 | 274 | 16 | 0.98 | 0.71-1.37 |
 Pigmentation | 33 | 215 | 15 | 11 | 123 | 9 | 1.72 | 0.90-3.27 | 8 | 296 | 3 | 7 | 161 | 4 | 0.62 | 0.23-1.68 |
 Lethargy | 83 | 221 | 37 | 74 | 224 | 33 | 1.14 | 0.88-1.46 | 57 | 300 | 19 | 45 | 300 | 15 | 1.27 | 0.89-1.81 |
 Infected | 21 | 293 | 7 | 22 | 294 | 7 | 0.96 | 0.54-1.70 | 41 | 291 | 14 | 23 | 294 | 78 | 1.80 | 1.11-2.92 |
 Constipation | 62 | 286 | 22 | 41 | 193 | 21 | 1.02 | 0.72-1.45 | 0 | 286 | 0 | 5 | 193 | 0.06 | 0.06 | 0.00-1.10 |
 Fluid retention | 17 | 72 | 24 | 10 | 70 | 14 | 1.65 | 0.81-3.36 | 1 | 72 | 1.3 | 3 | 70 | 4 | 0.32 | 0.03-3.04 |
 Allergy | 5 | 72 | 7 | 5 | 70 | 7 | 0.97 | 0.29-3.21 | 1 | 72 | 1.3 | 1 | 70 | 1.3 | 0.97 | 0.06-15.24 |
 Abdominal pain | 33 | 170 | 19 | 21 | 78 | 27 | 0.72 | 0.45-1.16 | 6 | 170 | 3.5 | 4 | 78 | 5.1 | 0.69 | 0.20-2.37 |
Laboratory-assessed items | ||||||||||||||||
 Increased ALT | 28 | 149 | 19 | 28 | 144 | 19 | 0.97 | 0.60-1.55 | 0 | 149 | 0 | 1 | 144 | 0.6 | 0.32 | 0.01-7.85 |
 Increased AST | 35 | 104 | 34 | 21 | 99 | 21 | 1.59 | 1.00-2.53 | 0 | 104 | 0 | 1 | 99 | 1 | 0.32 | 0.01-7.70 |
 Increased ALP | 24 | 72 | 33 | 27 | 70 | 38 | 0.86 | 0.56-1.34 | 1 | 72 | 1.3 | 2 | 70 | 2.8 | 0.49 | 0.05-1.40 |
 Creatinine | 18 | 149 | 12 | 26 | 144 | 18 | 0.67 | 0.38-1.17 | 1 | 149 | 0.6 | 0 | 144 | 0 | 2.90 | 0.12-7.61 |