Longitudinal associations between BMI change and the risks of colorectal cancer incidence, cancer-relate and all-cause mortality among 81,388 older adults

Table 2 Associations between change in BMI status and the risk of CRC incidence, cancer-related mortality, and all-cause mortality among all participants stratified by BMI status at study entry

BMI change	No. of participants	Incident CRC				Cancer-related mortality				All-cause mortality
BMI change	No. of participants	No. of cases	HR	95% CI	p	No. of cases	HR	95% CI	p	No. of cases	HR	95% CI	p
Under/normal weight at study entry
Under/normal weight at follow-up	21,749	47	1.00	–	–	163	1.00	–		574	1.00	–	–
Overweight at follow-up	5781	19	1.24	0.69, 2.23	0.46	54	1.07	0.77, 1.50	0.67	113	0.69	0.56, 0.85	< 0.001
Obesity at follow-up	302	0	–	–	–	5	1.52	0.61, 3.77	0.37	12	1.13	0.63, 2.01	0.69
Overweight at study entry
Under/normal weight at follow-up	5244	16	1.02	0.58, 1.81	0.943	41	1.06	0.74, 1.51	0.76	261	1.85	1.59, 2.16	< 0.001
Overweight at follow-up	24,533	68	1.00	–	–	176	1.00	–	–	603	1.00	–	–
Obesity at follow-up	5044	13	0.93	0.49, 1.74	0.814	36	0.82	0.56, 1.20	0.315	132	0.86	0.70, 1.04	0.12
Obesity at study entry
Under/normal weight at follow-up	321	2	1.68	0.41, 7.00	0.472	4	1.35	0.50, 3.70	0.555	27	2.59	1.75, 3.85	< 0.001
Overweight at follow-up	3658	13	0.93	0.50, 1.74	0.812	38	1.20	0.82, 1.76	0.361	147	1.37	1.13, 1.67	0.002
Obesity at follow-up	14,755	63	1.00	–	–	131	1.00	–	–	492	1.00	–	–

CRC: Colorectal cancer; BMI: Body mass index; HR: Hazard ratio; 95% CI: 95% confidence interval. HRs were adjusted by cox regression models for sex, age, race, education level, family annual income, marital status, physical activity level, family history of cancer, smoking status, screening arm, history of chronic diseases (i.e., hypertension, heart attack, stroke, emphysema, diabetes, arthritis, and osteoporosis), and baseline BMI value (continuous) Boldface means statistically significance

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