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Table 3 Multivariable Cox model analyses

From: Relationship between WBRT total dose, intracranial tumor control, and overall survival in NSCLC patients with brain metastases - a single-center retrospective analysis

Variables

OS

iPFS

HR

95%CI

pa

HR

95%CI

pa

WBRT (Gy)

 none

1.000

 

ref.

1.000

 

ref.

  < 30

1.227

(0.787–1.914)

ns

1.625

(1.045–2.528)

0.031

 30–39

0.722

(0.500–1.042)

0.082

0.714

(0.502–1.017)

0.062

  ≥ 40

0.609

(0.453–0.818)

0.001

0.669

(0.500–0.895)

0.007

Local/boost RT (Gy)

 none

1.000

 

ref.

1.000

 

ref.

  < 50

0.609

(0.341–1.088)

0.042

0.930

(0.555–1.561)

ns

 50–59

0.572

(0.402–0.815)

0.003

0.776

(0.551–1.092)

0.146

  ≥ 60

0.580

(0.385–0.873)

0.019

0.641

(0.427–0.963)

0.032

SRT

0.653

(0.326–1.308)

0.022

0.708

(0.364–1.376)

ns

Female

0.798

(0.644–0.988)

0.039

0.804

0.655–0.987)

0.037

CVD

0.868

(0.706–1.068)

0.182

0.936

(0.765–1.145)

ns

Age (years)

  < 50

1.000

 

ref.

1.000

 

ref.

 50–59

1.089

(0.799–1.486)

ns

0.854

0.638–1.142)

ns

  ≥ 60

1.335

(0.990–1.800)

0.058

1.088

0.820–1.444)

ns

KPS

  < 70

1.000

 

ref.

1.000

 

ref.

 70–80

0.987

(0.762–1.279)

ns

0.964

(0.748–1.241)

0.774

  ≥ 90

0.620

(0.479–0.801)

0.000

0.670

(0.521–0.862)

0.002

NSCLC history (month)

  < 1

0.632

(0.473–0.844)

0.002

0.780

(0.595–1.023)

0.072

 1–6

0.895

(0.626–1.280)

ns

1.249

(0.891–1.750)

0.197

 6–12

0.741

(0.525–1.045)

0.087

0.828

(0.590–1.160)

ns

  > 12

1.000

 

ref.

1.000

 

ref.

BM lesion number

 1

1.000

 

ref.

1.000

 

ref.

 2–3

1.181

(0.870–1.602)

ns

1.023

(0.766–1.366)

ns

  ≥ 4

1.325

(1.045–1.681)

0.020

1.148

(0.911–1.447)

ns

Extracranial met.

1.313

(1.019–1.691)

0.035

1.836

(1.428–2.361)

0.000

Brain stem met.

1.219

(0.664–2.235)

ns

1.009

(0.548–1.857)

ns

Meningeal met.

0.935

(0.633–1.382)

ns

1.136

(0.772–1.670)

ns

Targeted therapy

0.373

(0.290–0.480)

0.000

0.506

(0.402–0.636)

0.000

Chemotherapy

0.587

(0.476–.724)

0.000

0.724

(0.592–0.885)

0.002

BM resection

 none

1.000

 

ref.

1.000

 

ref.

 incomplete

0.834

(0.200–3.482)

ns

0.854

(0.206–3.532)

ns

 complete

0.709

(0.429–1.171)

0.180

0.909

0.557–1.486)

ns

Lung tumor surgery

 none

1.000

 

ref.

1.000

 

ref.

 incomplete

0.889

(0.533–1.482)

ns

0.911

(0.559–1.483)

ns

 radical

0.773

(0.553–1.080)

0.132

0.705

(0.508–0.978)

0.036

  1. OS overall survival; iPFS intracranial progression-free survival; HR hazard ratio; 95%CI 95% confidence interval; WBRT whole brain radiotherapy; ref. reference; ns not significant with p > 0.20; RT radiotherapy; SRT stereotactic radiotherapy; CVD cardiovascular disease; BM brain metastases; KPS Karnofsky Performance Score; NSCLC non-small cell lung cancer; met. Metastases.
  2. a from the multivariable Cox model analysis.
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BMC Cancer

ISSN: 1471-2407

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